Mitochondrial Dysfunction in Metabolic Disease
نویسندگان
چکیده
منابع مشابه
Mitochondrial Dysfunction in Metabolic Syndrome and Asthma
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(mtDNA) disease and the frequency of cardiac involvement, at least 1 in 10–15,000 of the general population will be affected.4 In 1991, the first mtDNA point mutation in the MT-TL1 gene associated with an MCM was described.5 Since then, several mutations, mostly in mitochondrial tRNA genes, have been associated with different MCM phenotypes. At the end of the 20th century, mutations in several ...
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It is clear from a striking convergence of human tissue studies, neurotoxin models, and genetic models that mitochondrial dysregulation plays a central pathogenic role in Parkinson’s disease (PD) and related neurodegenerative conditions. Impaired mitochondrial quality could result from both increased damage and decreased ability to repair or clear damaged mitochondria. In particular, common def...
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ژورنال
عنوان ژورنال: The Indonesian Biomedical Journal
سال: 2012
ISSN: 2355-9179,2085-3297
DOI: 10.18585/inabj.v4i3.172